Naphthol AS-E phosphate, for histology

Naphthol AS-E phosphate, for histology

Stock Code: 3577978
Manufacturer Part No: 70485-250MG
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Application


Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).


Biochem/physiol Actions


Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.


Other Notes


Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.

Quality Level100
InChI keyRQAQWBFHPMSXKR-UHFFFAOYSA-N
InChI1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formpowder
Assay≥80% (HPLC)

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