Tn Antigen, >=99.0% (TLC)

Tn Antigen, >=99.0% (TLC)

Stock Code: 3577961
Manufacturer Part No: 53886-1MG
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Biochem/physiol Actions


Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.


General description


Tn antigenis a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.


Packaging


Bottomless glass bottle. Contents are inside inserted fused cone.

Quality Level100
InChI keyREDMNGDGDYFZRE-WKWISIMFSA-N
InChI1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder or crystals
Assay≥99.0% (TLC)

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