GF 109203X, synthetic, >=90% (HPLC)

Descriptions

Application

GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca²⁺ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca²⁺ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 µM.

Quantity

For PKC inhibition, typically used at a concentration of 0.1-10 µM.

Specifications

Quality Level	100
InChI key	QMGUOJYZJKLOLH-UHFFFAOYSA-N
InChI	1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,
Manufacturer	SIGMA-ALDRICH
Storage Temp.	2-8°C
Solubility	DMSO: soluble (~1 mg/ml)
Assay	≥90% (HPLC)