Chlorothiazide, thiazide diuretic

Stock Code: 3577678
Manufacturer Part No: C4911-50G

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Descriptions

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.

One of the first in the thiazide class of diuretics. The effect is sparing of calcium and lithium, but increases the excretion of sodium.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

General description

Chlorothiazide (CTLD) is a thiazide-like diureticsand has antihypertensive effects.

Packaging

50 g in glass bottle

Specifications

Quality Level	100
mp	>300 °C
InChI key	JBMKAUGHUNFTOL-UHFFFAOYSA-N
InChI	1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥98% (HPLC)