RS 23597-190

RS 23597-190

Stock Code: 3575535
Manufacturer Part No: SML1909-5MG
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£107.53 (exc VAT) per 5MG
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Biochem/physiol Actions


RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 &mu;/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB &lt;5/guinea-pig ileum), dopamine receptors (pKi &lt;4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi ﹤5.2).


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyQLZLBYYNMGQIAR-UHFFFAOYSA-N
InChI1S/C16H23ClN2O3.ClH/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19;/h10-11H,2-9,18H2,1H3;1H
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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