MITOTANE

Stock Code: 3575507
Manufacturer Part No: SML1885-100MG

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Descriptions

Biochem/physiol Actions

Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibition of SOAT1 in adrenocortical carcinoma cells decreased the formation of cholesteryl esters, which increased free cholesterol levels and caused endoplasmic reticulum (ER) stress, the unfolded protein response, and eventually apoptosis.

Packaging

100 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	JWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI	1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 20 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)