THAPSIGARGIN READY MADE SOLUTION

THAPSIGARGIN READY MADE SOLUTION

Stock Code: 3575452
Manufacturer Part No: SML1845-4MG
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£1,002.86 (exc VAT) per 4MG
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Application


Thapsigargin Ready Made Solution has been used as a negative control in in vivo growth and in vitro translation measurements.


Biochem/physiol Actions


Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues.


Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. The inhibition of calcium ion pumps causes intracellular increase of calcium ion levels. It was found that thapsigargin at 100 nM concentration effectively inhibited the SR Ca2+- adenosine triphosphatase (ATPase) in cardiac and skeletal muscles. Thapsigargin was also reported to be effective in blocking autophagy by interfering with the autophagosome-lysosome fusion.


Other Notes


Thapsigargin Ready Made Solution is provided at 10 mM concentration in DMSO. The solution can be further diluted with DMSO to a concentration of 2 mM. It is recommended to store Thapsigargin Ready Made Solution in small aliquots at -20 °C.

Quality Level200
InChI keyIXFPJGBNCFXKPI-FSIHEZPISA-N
InChI1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,
ManufacturerSIGMA-ALDRICH
FormDMSO solution
Assay≥98% (HPLC)

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