DEOXYNIVALENOL READY MADE SOLUTION

DEOXYNIVALENOL READY MADE SOLUTION

Stock Code: 3575236
Manufacturer Part No: SML1664-1ML
Order Now for 7 day delivery
£196.39 (exc VAT) per 1ML
Quantity: - +

Biochem/physiol Actions


Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.


Preparation Note


Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 µg/ml (1:1000).

Quality Level200
InChI keyLINOMUASTDIRTM-QGRHZQQGSA-N
InChI1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
ManufacturerSIGMA-ALDRICH
Formsolution (ethanol: 2-propanol 95:5)

There are no downloads for this product.