SBI-0640756

Stock Code: 3575208
Manufacturer Part No: SML1645-5MG

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Descriptions

Biochem/physiol Actions

SBI-0640756 is a potent inhibitor of eIF4G1 that disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	VVWGPQZBDQVQRC-RMKNXTFCSA-N
InChI	1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)