LMT-28 98% (HPLC)

LMT-28 98% (HPLC)

Stock Code: 3575184
Manufacturer Part No: SML1628-5MG
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Biochem/physiol Actions


LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). Its binding to gp130) results in inhibition of IL-6 activation, and downregulation of levels of p-STAT3. LMT-28 was shown to stimulate phosphorylation of STAT3 and JAK2 protein. IL-6 dysregulation is involved in inflammation and cancers. LMT-28 had inhbitory activity against IL-6–dependent TF-1 cell proliferation and also had therapeutic effect against pancreatitis.


LMT-28 is a derivative of oxazolidinone. It has the ability to repress the activation of signal transducer and activator of transcription 3 (STAT3) stimulated by interleukin 6 (IL-6). Orally administered LMT-28 reduced arthritis and acute pancreatitis stimulated by collagen in mice pathologic models.

Colourcolorless to light yellow, oil
Quality Level100
InChI keyUDXWSYOXIRPYFK-RRFJBIMHSA-N
InChI1S/C17H29NO4/c1-6-7-8-9-12(4)15(19)13(5)16(20)18-14(11(2)3)10-22-17(18)21/h11,13-15,19H,4,6-10H2,1-3,5H3/t13-,14+,15+/m0/s1
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formoil
Assay≥98% (HPLC)

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