S14161

S14161

Stock Code: 3575104
Manufacturer Part No: SML1571-1MG
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£93.18 (exc VAT) per 1MG
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Biochem/physiol Actions


S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.


Packaging


1, 5 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyBFZXDHIUPNWOMT-UHFFFAOYSA-N
InChI1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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