LEUCINOSTATIN A+B MIXTURE

LEUCINOSTATIN A+B MIXTURE

Stock Code: 3575096
Manufacturer Part No: SML1566-1MG
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Biochem/physiol Actions


Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus. Leucinostatins display broad bio-activity against gram-positive bacteria, fungi, plants and tumor cell lines. They play a role as uncouplers in the inner mitochondria membrane and inhibit mitochondrial ATP synthesis. Recently, interest in Leucinostatins has focused on other aspects such as understanding their activity: insulin-like growth factor I regulators, ionophore, inhibitors of cell surface expression of viral glycoproteins and their potent in vitro and in vivo anti-trypanosomal activity.


Components


Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13).


Other Notes


Stable at −20 °C for at least 2 years.

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMF: 10 mg/mL, methanol: 10 mg/mL, DMSO: 10 mg/mL, ethanol: 10 mg/mL
Formpowder
Assay≥95% (mixture of Leucinostatin A+B, HPLC)

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