DMH2

DMH2

Stock Code: 3575048
Manufacturer Part No: SML1535-5MG
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Biochem/physiol Actions


DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.


General description


DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyDXLXRNZCYAYUED-UHFFFAOYSA-N
InChI1S/C27H25N5O2/c1-2-4-26-24(3-1)23(9-10-28-26)25-18-30-32-19-21(17-29-27(25)32)20-5-7-22(8-6-20)34-16-13-31-11-14-33-15-12-31/h1-10,17-19H,11-16H2
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 1 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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