SMBA1

Stock Code: 3574946
Manufacturer Part No: SML1464-5MG

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Descriptions

Biochem/physiol Actions

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	PEYKRJBXACUOOB-WOJGMQOQSA-N
InChI	1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 20 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)