AZ3146

Stock Code: 3574898
Manufacturer Part No: SML1427-5MG

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Descriptions

Biochem/physiol Actions

AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC₅₀ = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to light brown
Quality Level	100
InChI key	YUKWVHPTFRQHMF-UHFFFAOYSA-N
InChI	1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 2 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)