NIFETEPIMINE

Stock Code: 3574820
Manufacturer Part No: SML1372-25MG

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Descriptions

Biochem/physiol Actions

Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca²⁺ -ATPase 3) pump, and protects of the CD4⁺ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	PPBNQKLDXXHPMH-UHFFFAOYSA-N
InChI	1S/C14H15N3O5/c1-3-22-13(18)11-8(2)15-14(19)16-12(11)9-5-4-6-10(7-9)17(20)21/h4-7,12H,3H2,1-2H3,(H2,15,16,19)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 10 mg/mL, clear
Form	powder
Assay	≥95% (HPLC)