VU0453379 HYDROCHLORIDE

Stock Code: 3574798
Manufacturer Part No: SML1357-25MG

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Descriptions

Biochem/physiol Actions

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC₅₀ = 1.3 µ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson’;s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	OCMGNMGYQPPMFF-FYZYNONXSA-N
InChI	1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-
Manufacturer	SIGMA-ALDRICH
Solubility	H2O: 20 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)