CINK4

CINK4

Stock Code: 3574790
Manufacturer Part No: SML1352-25MG
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Biochem/physiol Actions


CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
InChI keyYVXCDLCJCIDFHE-AFARHQOCSA-N
InChI1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

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