API-1

Stock Code: 3574776
Manufacturer Part No: SML1342-5MG

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Descriptions

Biochem/physiol Actions

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	SPBWHPXCWJLQRU-FITJORAGSA-N
InChI	1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 1 mg/mL, clear (warmed)
Form	powder
Assay	≥95% (HPLC)