L-779450

Stock Code: 3574771
Manufacturer Part No: SML1338-25MG

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Descriptions

Biochem/physiol Actions

L-779450 is a potent inhibitor in Raf-induced proliferation of Raf-1 and A-Raf-1 kinases. Raf inhibition is a target for anti-cancer therapy. Raf exists in three isoforms: Raf-1, A-Raf, and B-Raf, which are expressed at different levels in different cell types, tissues, and cancer states. L-779450 compound′s pharmacology found it to inhibit proliferation in Raf-1 and A-Raf, but not B-Raf responsive cells. L-779450 has been used as a reference Raf inhibitor to discover other compounds.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	WXJLXRNWMLWVFB-UHFFFAOYSA-N
InChI	1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 10 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)