YZ9

Stock Code: 3574687
Manufacturer Part No: SML1270-10MG

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Descriptions

Biochem/physiol Actions

YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC₅₀ = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.

YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.

Packaging

10, 50 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	IETDBZQIWIJQJG-UHFFFAOYSA-N
InChI	1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3
Manufacturer	SIGMA-ALDRICH
Storage Temp.	−20°C
Solubility	DMSO: 5 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)