CCT137690

Stock Code: 3574633
Manufacturer Part No: SML1237-5MG

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Descriptions

Biochem/physiol Actions

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC₅₀ = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	GFLQCBTXTRCREJ-UHFFFAOYSA-N
InChI	1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 2 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)