CGAMP SODIUM SALT

CGAMP SODIUM SALT

Stock Code: 3574629
Manufacturer Part No: SML1232-.5UMO
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Application


cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.


Biochem/physiol Actions


Cyclic AMP-GMP (cGAMP) is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c-AMP-GMP promotes intestinal colonization by down-regulating chemotaxis. During infections bacterial cGAMP is bound by host STING (stimulator of interferon genes) activating innate immune responses leading to expression of interferon genes.


cGAMP induces the formation of cytokines (interferon-?, interferon-?), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.


Preparation Note


Cyclic AMP-GMP is soluble in water and aqueous buffers (> 10 mM, limits have not been determined).

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Further Infocontains 0.5µmol of powder (approx. 0.335mg)
Storage Temp.−20°C
Formpowder
Assay≥98% (HPLC)

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