CZC24832

CZC24832

Stock Code: 3574607
Manufacturer Part No: SML1214-5MG
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Biochem/physiol Actions


CZC24832 is a potent and selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with Kd app of 19 nM. CZC24832 is said to be the first selective PI3Kγ inhibitor with efficacy in in vitro and in vivo models of inflammation. CZC24832 strongly inhibited T-cell interleukin 17A (IL-17A) production by inhibiting expression of retinoic acid receptor–related orphan receptor γt (RORγt), a transcription factor that drives TH17 differentiation, showing a new role for PI3Kγ.

Colourwhite to beige
Quality Level100
InChI keyRXRZPHQBTHQXSV-UHFFFAOYSA-N
InChI1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10/h4-8,21H,1-3H3,(H2,17,20)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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