ROMIDEPSIN

Stock Code: 3574567
Manufacturer Part No: SML1175-1MG

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Descriptions

Biochem/physiol Actions

Romidepsin promotes apoptosis, while hindering tumor growth in glioma models.

Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2 that is converted to active form by glutathione. Romidepsin has IC₅₀ values of 36 nM and 47 nM for HDAC1 and HDAC2, respectively. Romidepsin kills lymphoma cell lines overexpressing Bcl-2 and Bcl-XL, and has been approved for the treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma, and a variety of other cancers.

Packaging

1 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	OHRURASPPZQGQM-GCCNXGTGSA-N
InChI	1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥98% (HPLC)