MG-132(R)

MG-132(R)

Stock Code: 3574512
Manufacturer Part No: SML1135-5MG
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Biochem/physiol Actions


MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.


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SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

Quality Level200
InChI keyTZYWCYJVHRLUCT-ZRBLBEILSA-N
InChI1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)
ManufacturerSIGMA-ALDRICH
Product LineSAFC Hitech®
Formpowder
Assay≥95% (HPLC)

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