ETHACRYNIC ACID

Stock Code: 3574445
Manufacturer Part No: SML1083-10MG

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Descriptions

Biochem/physiol Actions

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Packaging

10 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	AVOLMBLBETYQHX-UHFFFAOYSA-N
InChI	1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥97% (HPLC)