CHIR99021

CHIR99021

Stock Code: 3574396
Manufacturer Part No: SML1046-25MG
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£605.89 (exc VAT) per 25MG
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Application


CHIR99021 has been used:in cocktail with small molecules to convert human lung fibroblast cells into neuronsas a culture medium supplement in potassium supplemented simplex optimization medium (KSOM) for the culture of blastocystsfor chronic inhibition of GSK-3 to investigate its role in corticogenesis


Biochem/physiol Actions


CHIR99021 is a very potent inhibitor of Glycogen synthase kinase 3 (GSK3, IC50 values for GSK3α and GSK3β = 10 and 6.7 nM, respectively). There is no cross-reactivity against CDKs. CHIR99201 potentiates self-renewal of human and mouse embryonic stem cells, and enhances reprogramming of somatic cells into stem cells.


General description


CHIR99021 is an aminopyrimidine derivative. CHIR99021 promotes self-renewal potential of embryonic stem cells (ESCs) of mice by inhibiting glycogen synthase kinase-3 (GSK-3) activity and potentiates the upregulation of ?-catenin and c-Myc functions. CHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor ? (TGF-?), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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