KC7F2

KC7F2

Stock Code: 3574390
Manufacturer Part No: SML1043-1MG
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Biochem/physiol Actions


KC7F2 is a cell permeable potent HIF-1 pathway inhibitor. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1? in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Other Notes


air sensitive


Packaging


1, 5 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyREQLACDIZMLXIC-UHFFFAOYSA-N
InChI1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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