MECLIZINE DIHYDROCHLORIDE

MECLIZINE DIHYDROCHLORIDE

Stock Code: 3574285
Manufacturer Part No: SML0950-50MG
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Biochem/physiol Actions


Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ?nutrient-sensitized? chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6?-hydroxylation in primary cultures of human hepatocytes.


Meclizine is a potent histamine H1 receptor antagonist that is widely used as antiemetic. Recently, meclizine was identified as an inhibitor of hepstin. Also, meclizine is a potent inhibitor of mitochondrial respiration through inhibition of cytosolic CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).


Features and Benefits


This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyVCTHNOIYJIXQLV-UHFFFAOYSA-N
InChI1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥97% (HPLC)

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