GOSSYPIN

GOSSYPIN

Stock Code: 3574112
Manufacturer Part No: SML0761-50MG
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£152.07 (exc VAT) per 50MG
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Biochem/physiol Actions


Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.


General description


Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces ?-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.


Packaging


50 mg in glass bottle

Colour, light yellow to dark green-yellow
Quality Level100
InChI keySJRXVLUZMMDCNG-KKPQBLLMSA-N
InChI1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥90% (HPLC)

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