SIS3, >=98% (HPLC), powder

SIS3, >=98% (HPLC), powder

Stock Code: 3573885
Manufacturer Part No: S0447-5MG
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£470.79 (exc VAT) per 5MG
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Application


Sugar insensitive 3 (SIS3) has been used as smad3inhibitor in various cells.


Biochem/physiol Actions


SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3


Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.


Packaging


5 mg in glass bottle

Colouryellow
Quality Level100
InChI keyCDKIEBFIMCSCBB-CALJPSDSSA-N
InChI1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H
ManufacturerSIGMA-ALDRICH
SolubilityH2O: ﹤2 mg/mL, DMSO: >20 mg/mL
Formpowder
Assay≥98% (HPLC)

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