RG108, >=98% (HPLC), powder

RG108, >=98% (HPLC), powder

Stock Code: 3573882
Manufacturer Part No: R8279-10MG
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Application


RG108 has been used:in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cellsas a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)


Biochem/physiol Actions


RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.


RG108 is less cytotoxic compared to azacytidine (5-Aza-dCR). It mediates radiosensitivity in esophageal cancer cells (EC). RG108 is a potent epigenetic modulator and a demethylating agent. It elicits non-cytotoxic functionality and may be useful in stem cell therapiesbased on human bone marrow-derived mesenchymal stem cells (hBMSCs). It interacts with DNA methyltransferase 1 at the catalytic domain region.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


General description


RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.


Packaging


10 mg in glass bottle

Colouryellow
Quality Level100
InChI keyLMAZUAXDZRILNJ-INIZCTEOSA-N
InChI1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: >10 mg/mL
Formpowder
Assay≥98% (HPLC)

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