PB28 dihydrochloride, >=98% (HPLC), solid

Stock Code: 3573546
Manufacturer Part No: P9246-5MG

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Descriptions

Application

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.

Biochem/physiol Actions

Selective σ₂opioid receptor ligand; putative σ₂ agonist

PB28, a cyclohexylpiperazine derivative, is a sigma 1 (?1)-R antagonist. It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.

Specifications

Colour	white
Quality Level	100
InChI key	DSRBJOQIBXACIV-UHFFFAOYSA-N
InChI	1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
Manufacturer	SIGMA-ALDRICH
Solubility	H2O: ~10 mg/mL at 60 °C
Form	solid
Assay	≥98% (HPLC)