NS1643

NS1643

Stock Code: 3573488
Manufacturer Part No: N0663-5MG
Order Now for 21 day delivery
Click Add to Quote for price and delivery
Quantity: - +

Biochem/physiol Actions


The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.


Features and Benefits


This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to off-white
Quality Level100
InChI keyNJFVQMRYJZHGME-UHFFFAOYSA-N
InChI1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: ≥20 mg/mL
Formsolid
Assay≥98% (HPLC)

There are no downloads for this product.