Matrix Metalloproteinase-12, Catalytic Domain human, recombinant, expressed in E. coli, >=95% (SDS-P

Matrix Metalloproteinase-12, Catalytic Domain human, recombinant, expressed in E. coli, >=95% (SDS-P

Stock Code: 3573485
Manufacturer Part No: M9695-10UG
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Biochem/physiol Actions


Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.


MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.


General description


Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.


Legal Information


Brij is a registered trademark of Croda International PLC


Physical form


Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 µM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.


Unit Definition


One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−70°C
Formbuffered aqueous glycerol solution
Assay≥95% (SDS-PAGE)

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