GGTI 298 trifluoroacetate salt hydrate, >=90% (HPLC), film

Stock Code: 3573385
Manufacturer Part No: G5169-1MG

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Descriptions

Application

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:to study the anticancer effects of statins along with GGTI 298to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endotheliumto evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population

Biochem/physiol Actions

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Specifications

Colour	colorless
mp	99.5-100 °C
InChI key	WALKWJPZELDSKT-UFABNHQSSA-N
InChI	1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,2
Manufacturer	SIGMA-ALDRICH
Impurities	﹤10% dimer
Form	lyophilized, film
Assay	≥90% (HPLC)