FLAVOPIRIDOL HYDROCHLORIDE HYDRATE

FLAVOPIRIDOL HYDROCHLORIDE HYDRATE

Stock Code: 3573373
Manufacturer Part No: F3055-25MG
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Application


Flavopiridol hydrochloride hydrate has been used:as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblastsas an RNA polymerase inhibitor to study its effects on hepatic cellsas RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo


Biochem/physiol Actions


Flavopiridol hydrochloride is a potent CDK (cyclin-dependent kinase), and a CDC25 phosphatase family inhibitor.


Flavopiridolis a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).


Features and Benefits


This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
InChI keyLGMSNQNWOCSPIK-LWHGMNCYSA-N
InChI1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: ﹥5 mg/mL; H2O: ~2 mg/mL
Formpowder
Assay≥98% (HPLC)

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