Enniatin B, from Gnomonia errabunda, >=95% (HPLC)

Stock Code: 3573361
Manufacturer Part No: E5411-1MG

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Descriptions

Biochem/physiol Actions

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.

Specifications

Quality Level	200
InChI key	MIZMDSVSLSIMSC-VYLWARHZSA-N
InChI	1S/C33H57N3O9/c1-16(2)22-31(40)43-26(20(9)10)29(38)35(14)24(18(5)6)33(42)45-27(21(11)12)30(39)36(15)23(17(3)4)32(41)44-25(19(7)8)28(37)34(22)13/h16-27H,1-15H3/
Manufacturer	SIGMA-ALDRICH
Storage Temp.	−20°C
Solubility	methanol: 10 mg/mL, DMSO: 10 mg/mL, ethanol: 10 mg/mL
Assay	≥95% (HPLC)