DMXAA, >=98% (HPLC), solid

DMXAA, >=98% (HPLC), solid

Stock Code: 3573335
Manufacturer Part No: D5817-5MG
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Application


5,6-dimethylxanthenone-4-acetic acid (DMXAA) has been used to induce type-I IFN signaling in a stimulator of interferon genes (STING) dependent manner. It has also been used to study STING-dependent signaling in the absence of infection.


Biochem/physiol Actions


DMXAA is an apoptosis inducer; anti-vascular.


Features and Benefits


This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


General description


5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.


Packaging


5, 25 mg in glass bottle

Colourlight brown
Quality Level100
InChI keyXGOYIMQSIKSOBS-UHFFFAOYSA-N
InChI1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: soluble >10 mg/mL
Formsolid
Assay≥98% (HPLC)

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