CI 976, , >98% (HPLC), solid

CI 976, , >98% (HPLC), solid

Stock Code: 3573314
Manufacturer Part No: C3743-5MG
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Application


CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells to treat Neuro-2a cells to test its effect on plasma membrane integrated density of ?4-SEP?2 or ?6-SEP?2?3 nicotinic acetylcholine receptors (nAChRs)to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells


Biochem/physiol Actions


CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.


Packaging


5 mg in glass bottle

Quality Level100
InChI keyWAFNZAURAWBNDZ-UHFFFAOYSA-N
InChI1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: >10 mg/mL, H2O: insoluble ﹤2 mg/mL
Formsolid
Assay>98% (HPLC)

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