Heparan sulfate proteoglycan, >=400 mug/mL glycosaminoglycan, sterile-filtered

Heparan sulfate proteoglycan, >=400 mug/mL glycosaminoglycan, sterile-filtered

Stock Code: 3571859
Manufacturer Part No: H4777-.1MG
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Application


Heparan Sulfate promotes the attachment of cells in culture and induces high affinity binding of FGF-basic to cells deficient in heparin sulfate and soluble FGF receptors at a concentration of 10-100 ng/mL.


Biochem/physiol Actions


This is a multifunctional molecule. As a component of the extracellular matrix that binds to fibroblast growth factors, vascular endothelial growth factor and vascular endothelial growth factor receptors. It also acts as a docking molecule for matrilysin and other matrix metalloproteinases.


Caution


It is recommended to store this product at 20°C, where it will retain its function for 3 years


Components


Heparan sulfate proteoglycan is a large biomolecule composed of a core protein covalently bound to heparin sulfate chains that is an integral part of the basement membrane. The number of polysaccharide chains and the size of the core protein are variable according to the source.


Preparation Note


This product is isolated from the basement membrane of Engelbreth-Holm-Swarm mouse sarcoma in a solution containing 50 mM Tris HCl at pH 7.4, 150 mM NaCl, 1 mM EDTA, and 0.1 mM PMSF.

Quality Level300
ManufacturerSIGMA-ALDRICH
Further InfoIsolated from basement membrane of Engelbreth-Holm-Swarm mouse sarcoma., Solution in 50 mM Tris HCl, 150 mM NaCl, 1 mM EDTA, 0.1 mM PMSF, pH 7.4, containing &g
Impurities≥100 µg/mL Uronic acid
Formsolution

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