Biglycan from bovine articular cartilage, essentially salt-free, lyophilized powder (from a sterile-

Biglycan from bovine articular cartilage, essentially salt-free, lyophilized powder (from a sterile-

Stock Code: 3571403
Manufacturer Part No: B8041-.5MG
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Biochem/physiol Actions


Biglycan interacts with collagen type I and II, fibronectin and TGF-ß. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-ß on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.


Caution


Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.


Components


Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.


Packaging


0.5 mg in glass bottle


Preparation Note


This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 µm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

Quality Level200
ManufacturerSIGMA-ALDRICH
Solubilitywater: soluble ≥2.00 mg/mL, clear, colorless
Formessentially salt-free, lyophilized powder (from 0.2 µm filtered solution), (essentially salt-free (from 0.2 µm filtered solution))

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