5-Azacytidine, Hybri-Max, gamma-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

5-Azacytidine, Hybri-Max, gamma-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Stock Code: 3571290
Manufacturer Part No: A1287-1VL
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Application


Used to study the effects of the DNA incorporated molecule on DNA methylation processes.


5-Azacytidine may be used to induce in vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. It may also be used to study the effects of 5-Azacytidine on the immune regulatory myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs).


Biochem/physiol Actions


A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.


5-Azacytidine is a deoxycytidine analog and a demethylating agent. It acts as a potential antineoplastic agent for acute myelogenous leukemia. 5-Azacytidine activates repressed genes by inhibiting DNA methylation. 5-Azacytidine also affects protein synthesis by altering the RNA function and stability.


General description


Chemical structure: nucleoside


Legal Information


Hybri-Max is a trademark of Sigma-Aldrich Co. LLC


Reconstitution


Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500ml medium. Final working concentration: 10 µM 5-azacytidine.

InChI keyNMUSYJAQQFHJEW-KVTDHHQDSA-N
InChI1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
ManufacturerSIGMA-ALDRICH
Impuritiesendotoxin, tested
Formlyophilized powder

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