E-Selectin; Human; Recombinant; CHO Cells

E-Selectin; Human; Recombinant; CHO Cells

Stock Code: 3571281
Manufacturer Part No: 561300-50UG
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Biochem/physiol Actions


Shown to bind to E-selectin ligands on U937 cells.


General description


Recombinant, human E-selectin consisting of 535 amino acids minus the transmembrane and cytoplasmic domains expressed in CHO cells. This glycoprotein is transiently expressed on vascular endothelial cell surfaces where it is able to bind to ligands such as SLex found on leukocytes. This initial binding event is followed by a second interaction involving ICAM and VCAM-1 that leads to vascular penetration and leukocyte invasion into the extracellular matrix tissue.


Recombinant, human E-selectin consisting of 535 amino acids minus the transmembrane and cytoplasmic domains expressed in CHO cells. This glycoprotein is transiently expressed on vascular endothelial cell surfaces where it is able to bind to ligands, such as sialyl Lewis x found on leukocytes. This initial binding event is followed by a second interaction involving ICAM and VCAM-1 that leads to vascular penetration and leukocyte invasion into the extracellular matrix tissue.


Legal Information


CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Packaging


50 µg in Plastic ampoule


Physical form


Lyophilized from Dulbecco′s PBS with stabilizer.


Reconstitution


Reconstitute to 1 mg/ml with sterile H2O.


Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.


Warning


Toxicity: Standard Handling (A)

Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Impurities﹤1 EU/µg Endotoxin (EU/µg of E-Selectin)
Formlyophilized
Assay≥95% (SDS-PAGE)

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