Galectin-3C; Human; Recombinant; E. coli

Galectin-3C; Human; Recombinant; E. coli

Stock Code: 3571247
Manufacturer Part No: 345832-100UG
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General description


Recombinant, human galectin-3 expressed in E. coli and subsequently cleaved with Clostridium histolyticum collagenase type VII to yield galectin-3C. The resulting galectin-3C is purified by affinity chromatography. Galectin-3C is a truncated form of galectin-3 that contains the carbohydrate binding domain but lacks the 107 amino acids at the N-terminus of galectin-3. It is suggested to play a key role in autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetes.


Recombinant, human galectin-3 expressed in E. coli and subsequently cleaved with Clostridium histiolyticum collagenase type VII to yield galectin-3C. The resulting galectin-3C is purified by affinity chromatography. Galectin-3C is a truncated form of galectin-3 that contains the carbohydrate binding domain but lacks the 107 amino acids at the N-terminus of galectin-3. It is suggested to play a key role in autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetes.


Legal Information


CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Other Notes


Hoyer K.K., et al. 2004. Am. J. Pathol.164, 893.John C.M., et al. 2003. Clin. Cancer Res.9, 2374.Iurisci, I., et al. 2000. Clin Cancer Res6, 1389.Van Den Brule, F. A., et al. 2000. Int. J. Cancer89, 361.Inohara, H. 1999. Cancer85, 2475.Nakamura, M., et al. 1999. Int. J. Oncol.15, 143.Idikio, H., et al. 1998. Int. J. Oncol.12, 1287.Ochieng, J., et al. 1998. Biochim. Biophys. Acta.1379 97.Castronovo, V., et al. 1996. J. Pathol.179, 43.Liu, F.T., et al. 1996. Biochemistry35 6073.Schoeppner, H. L., et al. 1995. Cancer75, 2818.Massa, S.M., et al. 1993. Biochemistry32, 260.Oda, Y., et al. 1991. Gene99, 279.


Packaging


100 µg in Plastic ampoule


Physical form


Lyophilized from deionized water, 2µg lactose/µg lectin.


Reconstitution


Following reconstitution, aliquot and freeze (-20°C). Stock solutions (in the presence of a molar excess of lactose) are stable for up to 4 months at -20°C. For use in carbohydrate binding assays the solution should be dialyzed to remove the lactose stabilizer.


Warning


Toxicity: Standard Handling (A)

Quality Level100
Pack100UG
ManufacturerSIGMA-ALDRICH
Impurities≤1 EU/µg protein Endotoxin
Solubilitysterile PBS: 1 mg/mL
Formlyophilized
Assay≥95% (SDS-PAGE)

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