6-Hydroxy-DL-DOPA, >=98% (TLC), powder
Biochem/physiol Actions
Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.
6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.
Caution
Hygroscopic; photosensitive
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
| Colour | off-white |
|---|---|
| Quality Level | 200 |
| InChI key | YLKRUSPZOTYMAT-UHFFFAOYSA-N |
| InChI | 1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.), H2O: 3 mg/mL (Dissolve in oxygen-free boiled water containing 0 |
| Form | powder |
| Assay | ≥98% (HPLC) |
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