Gly-Pro-Arg-Pro, >=97% (HPLC)
Amino Acid Sequence
Gly-Pro-Arg-Pro
Application
Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the ? chain of fibrinogen (rFbg?C30), cloned and expressed in Pichia pastoris.
Biochem/physiol Actions
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (?-aminoethyl ether)-N,N,N?,N?-tetraacetic acid).
Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin. Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.
Inhibits fibrin polymerization.
General description
Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the ? chain of fibrin protein.
| Quality Level | 200 |
|---|---|
| InChI key | WXPZDDCNKXMOMC-AVGNSLFASA-N |
| InChI | 1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Assay | ≥95% (HPLC) |
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