D-Cycloserine, powder

D-Cycloserine, powder

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Application

D-Cycloserine (DCS) has been used:to study its effect on partner preference in Prairie Volesto study its effect on grooming behaviour of ratsto determine its minimum inhibitory concentration (MIC) on 48 multidrug resistant tuberculosis (MDR-TB) isolates using the broth microdilution methodto study its effect on mouse model of autism, using behavioural assays

Biochem/physiol Actions

D-cycloserine (DCS) was initially known as a tuberculostatic agent. It acts as a glutamatergic partial N-methyl-D-aspartate (NMDA) agonist. It binds at the glycine-binding site of the NMDA receptor and enable the opening of the NMDA channel. DCS has a an ability to improve various forms of learning and memory hence, this drug might be effective for improving social memory and cognition. DCS can be used as a potential therapeutic for psychiatric disorders such as phobias, social anxiety, obsessive-compulsive disorder, and posttraumatic stress disorder.

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.Mode of Resistance: D-Ala transport interference.

General description

Chemical structure: amino acid derivatives

Packaging

1, 5 g in poly bottle

Quality Level200
mp147 °C (dec.) (lit.)
InChI keyDYDCUQKUCUHJBH-UWTATZPHSA-N
InChI1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
ManufacturerSIGMA-ALDRICH
Formpowder

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