kappa-Casein from bovine milk, kappa-casein basis (electrophoresis), >=70% kappa-casein basis (elect
Application
?-Casein from bovine milk has been used:as a standard to quantify the casein concentration and to evaluate the ability of the bacterial strain to hydrolyze caseins released by HM Mozzarellain LPS-depleted cow?s milk protein preparation for lymphoproliferation assayas standard to quantify ?-casein concentration in skimmed milk samples by reversed-phase high-performance liquid chromatography (RP-HPLC)
Biochem/physiol Actions
?-Casein from bovine milk is an immunoglobulin E (IgE)-binding epitope belonging to the casein phosphoprotein family. ?-Casein is important to the electrostatic and steric stabilization of casein micelles suspensions. It resists calcium precipitation and therefore, stabilizes other caseins. ?-Casein has been a target of research for creating low-phenylalanine milk through gene modification, which is important for patients suffering from metabolic diseases such as phenylketonuria (PKU).
General description
Caseins constitute 80% of the total milk proteins in the cow. ?-Casein is one of the major allergens in cow milk. It is a glycosylated protein comprising galactose, galactosamine, and sialic acid. It exists as tri- or tetrasaccharides and occurs in different isoforms based on the number of oligosaccharides attached to it. ?-Casein has a hydrophobic N-terminus and a hydrophilic C-terminus region.
Packaging
1 g in poly bottle
100, 250 mg in poly bottle
| Quality Level | 200 |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Technique(s) | isoelectric focusing (IEF): suitable |
| Storage Temp. | −20°C |
| Form | lyophilized powder |
| Assay | ≥70% (PAGE) |
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